GE17-5269-02

MabSelect^™ Xtra

Cytiva 17-5269-02, pack of 200 mL

• UNSPSC Code: 41106500
• NACRES: NA.56

Propiedades

• ligand: recombinant protein A (E. coli)
• shelf life: Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
• packaging: pack of 200 mL
• manufacturer/tradename: Cytiva 17-5269-02
• storage condition: (20% Ehtanol)
• matrix: highly cross-linked agarose
• avg. part. size: 75 (d₅₀v is the median particle size of the cumulative volume distribution)
• cleaning in place: 2-12(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
• working range: 3-10(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
• capacity: ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)(Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.)
• suitability: suitable for bioprocess medium
• storage temp.: 2-8°C

Descripción

General description

MabSelect^™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect^™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.

Application

MabSelect^™ Xtra has the same recombinant Protein A ligand as MabSelect^™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect^™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect^™ Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect^™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect^™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

Features and Benefits

• Higher dynamic binding capacity than currently available Protein A chromatography media.
• Improved process economics through reduced raw materials costs and/or reduced number of cycles
• High purity capture due to high ligand selectivity and matrix hydrophilicity
• Slightly lower pressure/fLow properties compared to MabSelect^™ SuRe^™ and MabSelect

Analysis Note

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Legal Information

MabSelect is a trademark of Cytiva

SuRe is a trademark of Cytiva

Información de seguridad

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P235 - P241 - P280 - P303 + P361 + P353 - P501
• Storage Class: 3 - Flammable liquids