G0541
Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert N1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 100 kDa
species reactivity
rat
packaging
antibody small pack of 25 μg
technique(s)
dot blot: 1:1000
immunohistochemistry: 1:1000
western blot: 1:1000
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
rat ... Grin1(24408)
Immunogen
synthetic peptide representing the sequence of the N1 splice variant.
Application
Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert N1) antibody is suitable for dot blot, immunohistochemistry and western blot at a dilution of 1:1000.
Biochem/physiol Actions
NMDA receptors (NMDAR) are glutamate-gated ion channels. It is sensitive to N-methyl-D-aspartate (NMDA) and consists of several homologous subunits (NMDAR1). NMDAR is highly expressed in the central nervous system and involved in excitatory synaptic transmission as well as synaptic plasticity. The activity of NMDA receptors are modulated by glycine. It exhibits high calcium permeability and unique voltage-dependent sensitivity to magnesium. It has been reported that phosphorylated NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation.
Physical form
Lyophilized powder from 5 mM ammonium bicarbonate (some residual salt may be present)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jia-Dong Xia et al.
Asian journal of andrology, 20(4), 355-359 (2018-03-09)
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Kun Zeng et al.
Oncotarget, 8(39), 65009-65021 (2017-10-17)
We investigated the effects of lentivirus-mediated RNAi targeting of Nogo Receptor (
Tue G Banke et al.
Nature neuroscience, 6(2), 144-152 (2003-01-14)
N-methyl-D-aspartate (NMDA) receptors are highly expressed in the central nervous system and are involved in excitatory synaptic transmission as well as synaptic plasticity. Despite considerable structural and biophysical research, the mechanism behind activation of the NMDA receptor is still poorly
R S Zukin et al.
Trends in neurosciences, 18(7), 306-313 (1995-07-01)
Molecularly diverse forms of the NMDA-receptor subunit NRI are formed by alternative RNA splicing. Differential splicing of three exons generates as many as eight NRI splice variants, seven of which have been identified in cDNA libraries. The alternatively spliced exons
R L Foldes et al.
Gene, 147(2), 303-304 (1994-09-30)
Two cDNA clones representing previously unidentified human N-methyl-D-aspartate receptor (hNR1) subunit polypeptides were isolated and sequenced. Clone hNR1-4 was isolated from a human hippocampus cDNA library and was presumably generated by alternative RNA splicing in the 3' amino acid (aa)
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