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Merck
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Key Documents

F7057

Sigma-Aldrich

Folate Receptor 2 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)

Sinónimos:

FOLR2, Folate Receptor beta

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.56

biological source

human

Quality Level

100

recombinant

expressed in CHO cells

assay

≥95% (SDS-PAGE)

form

lyophilized

impurities

≤1.0 EU/μg endotoxin

UniProt accession no.

P14207

application(s)

cell analysis

storage temp.

−20°C

Gene Information

human ... FOLR2(2350)

Application

Folate Receptor 2 has been used in studies of the treatment of rheumatoid arthritis (RA) with Methotrexate (MTX). These studies have focused on transport of MTX through folate receptor 2 in RA synovial macrophages.

Biochem/physiol Actions

Folate Receptor 2 is a 38kDa protein that has a high affinity for folic acid and mediates 5-methyltetrahydrofolate to the inside of the cell.

Physical form

Lyophilized from PBS

Reconstitution

Reconstitute at 100 μg/ mL in PBS

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)

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