Todas las fotos(1)

Documentos

D7693

Dynasore monohydrate

Name: Dynasore monohydrate
Brand: SIGMA

Sinónimos:

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):

C₁₈H₁₄N₂O₄ · xH₂O

Número de CAS:

1202867-00-2

Peso molecular:

322.31 (anhydrous basis)

MDL number:

MFCD11045288

UNSPSC Code:

12352200

PubChem Substance ID:

329798784

NACRES:

NA.77

form

powder

Quality Level

100

storage condition

protect from light

color

off-white

solubility

DMSO: ≥10 mg/mL
H₂O: insoluble

storage temp.

−20°C

SMILES string

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

InChI key

FKWZHQSDBMSHTN-ZIOFAICLSA-N

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:

for priming fetal mesenchymal stem/stromal cells (fMSC)
in confocal microscopy
in wound healing/scratch and tube-formation assay
to analyse its effects on Coxsackievirus A9 (CAV9) infection
to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
in live imaging of cells

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies

Fischer E, et al

Clinical Cancer Research, clincanres-clinca0644 (2012)

Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary.

G J Hofmeyr et al.

BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)

Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

Tom Kirchhausen et al.

Methods in enzymology, 438, 77-93 (2008-04-17)

The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for

Dynasore disrupts trafficking of HSV proteins

Mues MB, et al.

Journal of Virology, JVI-00636 (2015)

Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study.

Richard H Tuligenga et al.

The lancet. Diabetes & endocrinology, 2(3), 228-235 (2014-03-14)

Type 2 diabetes increases the risk for dementia, but whether it affects cognition before old age is unclear. We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline. 5653 participants from

Ver todos los artículos relacionados

Contenido relacionado

Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico