D7000

Deoxycorticosterone acetate

• Sinónimos: 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate
• Fórmula empírica (notación de Hill): C₂₃H₃₂O₄
• Número de CAS: 56-47-3
• Peso molecular: 372.50
• Beilstein/REAXYS Number: 2570798
• EC Number: 200-275-9
• MDL number: MFCD00003660
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894065
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• sterility: non-sterile
• assay: ≥98% (HPLC)
• form: powder
• solubility: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• InChI key: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Gene Information: human ... NR3C2(4306)

Descripción

General description

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)