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C5874

Sigma-Aldrich

Cidofovir hydrate

≥98% (HPLC), powder, viral DNA synthesis inhibitor

Sinónimos:

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC; Cidovir, HPMPC, Vistide

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About This Item

Fórmula empírica (notación de Hill):
C8H14N3O6P · xH2O
Número de CAS:
113852-37-2
Peso molecular:
279.19 (anhydrous basis)
MDL number:
MFCD17215968
UNSPSC Code:
12352200
PubChem Substance ID:
329775105
NACRES:
NA.77

product name

Cidofovir hydrate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

solubility

deionized water: ≥5 mg/mL (warmed)

storage temp.

room temp

SMILES string

O.NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1

InChI

1S/C8H14N3O6P.H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);1H2/t6-;/m0./s1

InChI key

KLJYJZIIJLYJNN-RGMNGODLSA-N

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Biochem/physiol Actions

Selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H315

Hazard Classifications

Acute Tox. 3 Oral - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Supelco

PHR1593

Ganciclovir

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Sigma-Aldrich

R9644

Ribavirin

Phosphonoacetic acid 98%

Sigma-Aldrich

284270

Phosphonoacetic acid

Acyclovir Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1254

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Chlorhexidine ≥99.5%

Sigma-Aldrich

282227

Chlorhexidine

Methyl cellulose viscosity: 4,000 cP

Sigma-Aldrich

M0512

Methyl cellulose

Ryan N Jennings et al.
Journal of virology, 88(24), 14040-14049 (2014-09-26)
CD8(+) T cell responses are critical to the control of replication and reactivation associated with gammaherpesvirus infection. Type I interferons (IFNs) have been shown to have direct and indirect roles in supporting CD8(+) T cell development and function during viral
Jonathan Schelfhout et al.
Current medical research and opinion, 36(1), 43-50 (2019-09-07)
Objective: This study utilized a large, national US database to explore the impact of Cytomegalovirus (CMV) infection on hospital services utilization and costs during the first 100 days following allogeneic hematopoietic stem cell transplant (allo-HSCT).Methods: This retrospective, observational cohort study used
Joanna Jackowska et al.
Lasers in medical science, 34(7), 1433-1440 (2019-02-15)
Mechanical debulking of laryngeal papillomas is associated with voice disorders due to impairment of the vocal fold's mucosa. Intraepithelial injection of cidofovir reduces damage to the laryngeal structures and thus improves vocal parameters. The aim of our study was to
Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.
Vinod E Nambudiri et al.
JAMA dermatology, 149(9), 1068-1070 (2013-07-05)
Stephen D S McCarthy et al.
PLoS neglected tropical diseases, 10(1), e0004364-e0004364 (2016-01-12)
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human primate studies, differences in experimental methodologies make it difficult
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