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Merck
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Key Documents

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C4124

Sigma-Aldrich

Chromium picolinate

≥98% (HPLC)

Sinónimos:

Cr(pic)3, CrPic

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About This Item

Fórmula empírica (notación de Hill):
C18H12CrN3O6
Número de CAS:
14639-25-9
Peso molecular:
418.30
MDL number:
MFCD00068715
UNSPSC Code:
12352200
PubChem Substance ID:
329775054
NACRES:
NA.25

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

powder

loss

≤5% loss on drying

storage temp.

room temp

SMILES string

O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3

InChI

1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

InChI key

CBDQOLKNTOMMTL-UHFFFAOYSA-K

General description

Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.

Application

Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.

Biochem/physiol Actions

Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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E A Ott et al.
Journal of animal science, 77(11), 3022-3030 (1999-11-24)
Thoroughbred and Quarter Horse yearlings (n = 24; 335+/-7 d of age) were used in a 112-d feeding trial to determine whether chromium (Cr) supplementation would alter growth, development, and energy metabolism of growing horses on high-concentrate diets. The horses
L R Gentry et al.
Journal of animal science, 77(5), 1284-1294 (1999-05-26)
Thirty-two Suffolk wether lambs were fed for 84 d in a 2 x 2 factorial experiment using two levels of dietary protein (9.0 to 12.1% CP, low protein, LP; or 12.8 to 14.4% CP, high protein, HP) and supplemental Cr
M D Lindemann et al.
Journal of animal science, 82(10), 2972-2977 (2004-10-16)
A cooperative research study involving 353 litters was conducted at three stations to determine the effects of graded levels of supplemental Cr from chromium tripicolinate (CrPic) on reproductive performance of sows and preweaning performance of their pigs. Primiparous and multiparous
T L Ward et al.
Journal of animal science, 75(4), 1001-1008 (1997-04-01)
An experiment was conduct to determine the interactive effects of dietary chromium tripicolinate (CrPic), CP, and pen space (PS) as a stress on growth performance, carcass traits, and plasma hormones and metabolites of crossbred growing-finishing pigs (128 pigs; initial BW
D J Appleton et al.
Journal of feline medicine and surgery, 4(1), 13-25 (2002-03-01)
The effect of dietary chromium supplementation on glucose and insulin metabolism in healthy, non-obese cats was evaluated. Thirty-two cats were randomly divided into four groups and fed experimental diets consisting of a standard diet with 0 ppb (control), 150 ppb
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