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C1605

Sigma-Aldrich

Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone

powder, ≥95%

Sinónimos:

Z-VDVAD-FMK

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About This Item

Fórmula lineal:
C32H46N5O11F
Número de CAS:
210344-92-6
Peso molecular:
695.73
MDL number:
MFCD03452881
UNSPSC Code:
12352209
PubChem Substance ID:
329774898

biological source

synthetic (organic)

Quality Level

200

assay

≥95%

form

powder

color

white

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF

InChI

1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1

InChI key

ANTIWMNLIROOQF-IREHUOSBSA-N

Gene Information

human ... CASP2(835)
mouse ... CASP2(12366)
rat ... CASP2(64314)

Amino Acid Sequence

Z-Val-Asp-OMe-Val-Ala-Asp-OMe-FMK

Biochem/physiol Actions

A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Wolfgang W Quitschke
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Tropheryma whipplei, the etiological agent of Whipple's disease, is an intracellular bacterium that infects macrophages. We previously showed that infection of macrophages results in M2 polarization associated with induction of apoptosis and interleukin (IL)-16 secretion. In patients with Whipple's disease
Patrick Y Kim et al.
Apoptosis : an international journal on programmed cell death, 18(5), 639-651 (2013-02-14)
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication. Reduced TRIM16 expression in a range of human primary malignant tissues correlates with increased
Alex Chernyavsky et al.
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Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing a devastating blistering disease affecting oral and/or esophageal surfaces and, sometimes, also the skin. Anti-keratinocyte AuAbs developed by the
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