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Key Documents

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B175

Sigma-Aldrich

BW 723C86

≥98% (HPLC)

Sinónimos:

α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C16H18N2OS · HCl
Número de CAS:
160521-72-2
Peso molecular:
322.85
MDL number:
MFCD01321066
UNSPSC Code:
12352200
PubChem Substance ID:
24278284
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 1 mg/mL, clear

SMILES string

Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

InChI

1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

InChI key

PYJBJMIBANAOFJ-UHFFFAOYSA-N

Gene Information

human ... HTR2B(3357)

Biochem/physiol Actions

5-HT2B serotonin receptor agonist.

Caution

Hygroscopic; photosensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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G A Kennett et al.
Neuropharmacology, 36(2), 233-239 (1997-02-01)
The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min pre-test) also modestly increased
G A Kennett et al.
British journal of pharmacology, 117(7), 1443-1448 (1996-04-01)
1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2. The effect of BW 723C86 in
Marcus Niebert et al.
PloS one, 6(7), e21395-e21395 (2011-07-27)
Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase. However, there is one receptor family including 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors that are directed towards protein kinase
Raphael R Perim et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R709-R715 (2018-02-01)
Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT2) or type 7 (5-HT7) receptors elicits pMF, although they do so via distinct cellular mechanisms
Yasmine Chabbi-Achengli et al.
The American journal of pathology, 186(4), 927-937 (2016-03-13)
Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the cause of the disease is still unknown, evidence argues that
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