A9511

Albúmina from human serum

lyophilized powder, ≥97% (agarose gel electrophoresis)

• Sinónimos: HSA
• Número de CAS: 70024-90-7
• EC Number: 274-272-6
• MDL number: MFCD00081418
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Propiedades

• biological source: human
• Quality Level: 300
• assay: ≥97% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer calculated mol wt 66478 Da
• technique(s): ELISA: suitable; tissue culture: suitable; western blot: suitable
• impurities: HIV I and HIVII, HCV and HBsAg, tested negative
• solubility: H₂O: soluble 50 mg/mL
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Descripción

General description

Albumin is the most copious protein in blood plasma. Liver produces human albumin.

Human albumin possess a molecular weight of 67 kDa.

Application

Albumin from human serum has been used:

• to standardize the column for molecular-exclusion chromatography
• to prepare the tobacco mosaic virus (TMV)-poly ethylene glycol (PEG8)-serum albumin (SA) particles
• to analyze its modifications after oxidation using a Fenton system

Albumin-bound fluorescence was used in serum of patients with chronic renal failure.

Biochem/physiol Actions

La seroalbúmina funciona como una proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas, y es vital en la regulación de las presiones osmóticas coloidales de la sangre. También se ha observado que la albúmina se une a sustancias exógenas, en particular medicamentos (ibuprofeno, warfarina) y que influye fuertemente en su farmacocinética. El estrés oxidativo que induce cambios en el estado rédox de la albúmina tiene efectos muy variados sobre su función fisiológica.

Albumin turnover is seen in infants with iron deficiency anemia. Serum albumin is a reliable prognostic indicator in liver disease. Oxidative modification of albumin is seen in advanced liver disease.

Preparation Note

Prepared using method IV of Cohn, E.J., et al., J. Am. Chem. Soc., 69, 1753 (1947).

Other Notes

Encontrará más información en seroalbúmina humana.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves