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A3913

Sigma-Aldrich

L-Argininamide dihydrochloride

≥98%, suitable for ligand binding assays

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About This Item

Fórmula empírica (notación de Hill):
C6H15N5O · 2HCl
Número de CAS:
14975-30-5
Peso molecular:
246.14
MDL number:
MFCD00058286
UNSPSC Code:
12352209
PubChem Substance ID:
24890827
NACRES:
NA.26

Nombre del producto

L-Argininamide dihydrochloride,

assay

≥98%

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C6H15N5O.ClH/c7-4(5(8)12)2-1-3-11-6(9)10;/h4H,1-3,7H2,(H2,8,12)(H4,9,10,11);1H/t4-;/m0./s1

InChI key

BPQLYFCEVVKLLX-WCCKRBBISA-N

Application

L-Argininamide dihydrochloride has been used as an additive to compare its effect over L-arg in egg lysozyme refolding studies. It has also been used as a component of substrate stock solution for enzymatic kyotorphin synthesis.

Biochem/physiol Actions

L-Argininamide (L-Arm) is a hydrophilic amino acid derivative that is used as a model compound in physicochemical characteristic studies of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H370

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 1

target_organs

Eyes

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCF9587
BCBV9948
BCBQ1412V
BCBQ1412
BCBL5986V

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G Reid Bishop et al.
Biophysical chemistry, 126(1-3), 165-175 (2006-08-18)
The thermal stability and ligand binding properties of the L-argininamide-binding DNA aptamer (5'-GATCGAAACGTAGCGCCTTCGATC-3') were studied by spectroscopic and calorimetric methods. Differential calorimetric studies showed that the uncomplexed aptamer melted in a two-state reaction with a melting temperature T(m)=50.2+/-0.2 degrees C
Qi Zhang et al.
Science (New York, N.Y.), 311(5761), 653-656 (2006-02-04)
Using a domain elongation strategy, we decoupled internal motions in RNA from overall rotational diffusion. This allowed us to site-specifically resolve a manifold of motional modes in two regulatory RNAs from HIV-1 with the use of nuclear magnetic resonance spin
RNA dynamics by design: biasing ensembles towards the ligand-bound state.
Andrew C Stelzer et al.
Angewandte Chemie (International ed. in English), 49(33), 5731-5733 (2010-06-29)
Zece Zhu et al.
Chemical communications (Cambridge, England), 47(11), 3192-3194 (2011-01-29)
The nucleic acid minor groove binding dyes, DAPI and Hoechst 33258, were for the first time used in label-free aptamer-based sensors for L-argininamide. The synergy binding effect results in the enhancement of fluorescence of dyes. The method for detection of
Max Keller et al.
Bioorganic & medicinal chemistry, 19(9), 2859-2878 (2011-04-16)
Fluorescently labelled NPY Y(1) receptor (Y(1)R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y(1)R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most
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