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Merck
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Key Documents

A2202

Sigma-Aldrich

ω-Agatoxin TK

~98% (HPLC), powder

Sinónimos:

ω-Aga-TK

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About This Item

Fórmula empírica (notación de Hill):
C215H337N65O70S10
Número de CAS:
158484-42-5
Peso molecular:
5273.02
MDL number:
MFCD00286234
UNSPSC Code:
12352202
NACRES:
NA.32

assay

~98% (HPLC)

Quality Level

200

form

powder

solubility

H2O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)

storage temp.

−20°C

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Amino Acid Sequence

Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

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T Teramoto et al.
Biochemical and biophysical research communications, 196(1), 134-140 (1993-10-15)
In the course of purification of omega-Aga-IVA, a specific P-type calcium channel blocker, from the venom of Agelenopsis aperta we discovered a novel peptide. This peptide, named omega-agatoxin Tsukuba (omega-Aga-TK), also blocked P-type channels and was twelve times more abundant
Y Q Lin et al.
Journal of the autonomic nervous system, 73(1), 26-37 (1998-11-10)
The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in the terminal boutons, (delta[Ca2+]b) following short (1 or 5 impulses) and
T Teramoto et al.
Brain research, 756(1-2), 225-230 (1997-05-09)
We characterized the electrophysiological properties of calcium channels in cultured rat cerebral cortical neurons using omega-agatoxin-TK (omega-Aga-TK) by a patch-clamp technique. Two types of slowly inactivating calcium channels sensitive to omega-Aga-TK were detected. The first type showed high sensitivity to
T Teramoto et al.
Neuroreport, 6(12), 1684-1688 (1995-08-21)
We characterized the electrophysiological properties of calcium channels in cultured rat hippocampal neurones using omega-agatoxin-TK (omega-Aga-TK) and compared them with those of the P-type channel and the BI (alpha 1A) channel which resembles the Q-type channel. Two types of omega-Aga-TK-sensitive
Q Q Sun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(18), 6839-6849 (1997-09-15)
The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ currents. In approximately 80% of the acutely
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