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A0966

Sigma-Aldrich

4-Amino-1,8-naphthalimide

solid

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About This Item

Fórmula empírica (notación de Hill):
C12H8N2O2
Número de CAS:
1742-95-6
Peso molecular:
212.20
EC Number:
217-110-1
MDL number:
MFCD00006921
UNSPSC Code:
12352204
PubChem Substance ID:
24277696
NACRES:
NA.83

product name

4-Amino-1,8-naphthalimide,

form

solid

mp

360 °C

density

1.105 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

Nc1ccc2C(=O)NC(=O)c3cccc1c23

InChI

1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)

InChI key

SSMIFVHARFVINF-UHFFFAOYSA-N

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Biochem/physiol Actions

4-Amino-1,8-naphthalimide sensitizes cells to radiation-induced cell damage and enhances the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A Schlicker et al.
International journal of radiation biology, 75(1), 91-100 (1999-02-11)
Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) is a chromatin-bound enzyme which is known to regulate chromatin structure by poly(ADP-ribosyl)ation of nuclear proteins, to facilitate DNA base excision repair, and to contribute to cellular recovery following DNA damage. Because inhibitors of PARP
M Banasik et al.
The Journal of biological chemistry, 267(3), 1569-1575 (1992-01-25)
Two classes of enzymes, poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferases, catalyze covalent attachment of multiple or single residues, respectively, of the ADP-ribose moiety of NAD+ to various proteins. In order to find good inhibitors of poly(ADP-ribose) synthetase free of side actions and
Helen E Bryant et al.
Nucleic acids research, 34(6), 1685-1691 (2006-03-25)
Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage to activate pathways responsible for cellular survival. Here, we demonstrate that PARP-1-/- cells are sensitive to the ATM inhibitor KU55933 and conversely
Camille Godon et al.
Nucleic acids research, 36(13), 4454-4464 (2008-07-08)
The consequences of PARP-1 disruption or inhibition on DNA single-strand break repair (SSBR) and radio-induced lethality were determined in synchronized, isogenic HeLa cells stably silenced or not for poly(ADP-ribose) polymerase-1 (PARP-1) (PARP-1(KD)) or XRCC1 (XRCC1(KD)). PARP-1 inhibition prevented XRCC1-YFP recruitment
S García et al.
Annals of the rheumatic diseases, 67(5), 631-637 (2007-09-25)
To investigate the effect of poly(ADP-ribose) polymerase (PARP) inhibition on the production of inflammatory mediators and proliferation in tumour necrosis factor (TNF)-stimulated fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). Cultured FLS from patients with RA were treated with
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