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Merck
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Key Documents

145M-9

Sigma-Aldrich

CD45 (LCA) (2B11 & PD7/26) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

2B11 & PD7/26, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (145M-94)
vial of 0.5 mL concentrate (145M-95)
bottle of 1.0 mL predilute (145M-97)
vial of 1.0 mL concentrate (145M-96)
bottle of 7.0 mL predilute (145M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... PTPRC(5788)

Categorías relacionadas

General description

Anti-CD45 (anti-leukocyte common antigen) is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; therefore a positive result is highly indicative of hematolymphoid origin. Certain types of hematolymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of the hematopoietic lineage and is present in most benign and malignantlymphocytes as well as plasma cell precursors.

Quality


IVD
IVD
IVD
RUO

Linkage

CD45 (LCA) Positive Control Slides, Product No. 145S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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P J Kurtin et al.
Human pathology, 16(4), 353-365 (1985-04-01)
Immunohistochemical localization of human leukocyte common antigen (LCA), a major membrane glycoprotein restricted to leukocytes, was evaluated in paraffin sections of a wide variety of hematopoietic and nonhematopoietic tissues (294 specimens) with monoclonal antibodies (PD7/26 and 2B11). In nonneoplastic tissues
H M Maluf et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 8(2), 155-159 (1995-02-01)
Giant cell tumor of tendon sheath (GCTTS; "nodular tenosynovitis") and fibroma of tendon sheath (FTS) have traditionally been considered to be two points in a single neoplastic continuum. However, no systematic studies have addressed this concept directly to date. To
M A Vasef et al.
American journal of clinical pathology, 108(1), 54-59 (1997-07-01)
Other studies have shown that the immunophenotype of Reed-Sternberg and Hodgkin's (RS-H) cells in Hodgkin's disease commonly changes over time, as shown by examination of multiple biopsy specimens obtained from an individual patient. In this study we analyzed 96 sequential
A Saxena et al.
American journal of clinical pathology, 112(4), 495-512 (1999-10-08)
In the multiparametric evaluation of cutaneous B-cell infiltrates (CBIs), immunoarchitectural features have been underused, and B-cell clonality alone has limited clinical usefulness. Our aim was to assess the usefulness of immunoarchitectural abnormalities (IAs) and clonality in the diagnosis of CBIs.
T Caballero et al.
Journal of clinical pathology, 48(8), 743-748 (1995-08-01)
To gain new insights into the pathogenesis and differential diagnosis of ulcerative colitis and colonic Crohn's disease. Immunohistochemistry for different leucocyte subsets was performed in biopsy specimens of the sigmoid colon and rectum from 55 patients with inflammatory bowel disease
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