05260
L-Alanyl-L-1-aminoethylphosphonic acid
≥95% (HPLC)
Sinónimos:
(S)-Alanyl-(R)-1-aminoethylphosphonic acid, Alafosfalin, Alaphosphin
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About This Item
Fórmula empírica (notación de Hill):
C5H13N2O4P
Número de CAS:
Peso molecular:
196.14
Beilstein/REAXYS Number:
4801790
EC Number:
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
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assay
≥95% (HPLC)
form
powder
optical activity
[α]20/D −45±2°, c = 1% in H2O
color
white
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
SMILES string
C[C@H](N)C(=O)N[C@@H](C)P(O)(O)=O
InChI
1S/C5H13N2O4P/c1-3(6)5(8)7-4(2)12(9,10)11/h3-4H,6H2,1-2H3,(H,7,8)(H2,9,10,11)/t3-,4+/m0/s1
InChI key
BHAYDBSYOBONRV-IUYQGCFVSA-N
General description
Chemical structure: amino acid derivatives
Application
Alaphosphin is used as a selection agent for isolation of Salmonella and as a dipeptide mimetic antibacterial agent.
Biochem/physiol Actions
Alaphosphin is an antibacterial phosphonopeptide which mimics the terminal dipeptide moiety (D-Ala-D-Ala) of bacterial cell wall peptidoglycan . It metabolizes aminophosphonic acid which inhibits alanine racemase and uridine 5-diphosphate-N-acetylmuramoylalanine synthetase.
Alaphosphin is used as a selection agent for isolation of Salmonella and as a dipeptide mimetic antibacterial agent. It metabolizes aminophosphonic acid which inhibits alanine racemase and uridine 5-diphosphate-N-acetylmuramoylalanine synthetase.
Packaging
250MG
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.
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Los clientes también vieron
W H Traub
Chemotherapy, 26(2), 103-110 (1980-01-01)
Alaphosphin (Ro 03--7008; S-alanyl-R-1-aminoethyl-phosphonic acid) proved active against most of 53 strains of Serratia marcescens tested. The majority of strains were inhibited by less than or equal to 64 micrograms/ml of the drug; concentrations of greater than or equal to
[Antibiotics of the phosphonic acid group].
M S Poliak
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 32(1), 66-75 (1987-01-01)
Alafosfalin, a new synthetic antibacterial compound.
F E Hahn
Die Naturwissenschaften, 68(2), 90-90 (1981-02-01)
S F Grappel et al.
Antimicrobial agents and chemotherapy, 27(6), 961-963 (1985-06-01)
Alafosfalin, an antibacterial phosphonodipeptide requiring peptide transport for activity, was tested for activity against clinical strains of anaerobic bacteria in peptide-free Roche Sensitivity Test Medium no. 5 agar. It was active against Bacteroides spp., Fusobacterium nucleatum, and Clostridium perfringens but
F R Atherton et al.
Antimicrobial agents and chemotherapy, 18(6), 897-905 (1980-12-01)
Dipeptide variants of alafosfalin (L-alanyl-L-1-aminoethylphosphonic acid) with substantial differences in potency and antibacterial spectrum in vitro and in vivo have been synthesized. Certain dipeptides with alternatives to the L-alanyl residue had broader antibacterial spectra; activity against Pseudomonas aeruginosa was included.
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