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Y0000220

Roxithromycin for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Roxithromycin, Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime)

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About This Item

Fórmula empírica (notación de Hill):
C41H76N2O15
Número de CAS:
80214-83-1
Peso molecular:
837.05
MDL number:
MFCD00214389
UNSPSC Code:
41116107
PubChem Substance ID:
329830886
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

roxithromycin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O

InChI

1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+

InChI key

RXZBMPWDPOLZGW-FEMONOMJSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Roxithromycin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Related product

Referencia del producto
Descripción
Precios

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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[Asthma and infection: etiopathogenic factors and treatment with roxithromycin].
P R Calvo et al.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 12(1), 69-73 (1999-04-20)
E Bergogne-Bérézin
Presse medicale (Paris, France : 1983), 26 Suppl 2, 4-10 (1997-03-01)
MACROLIDES, one of the oldest antibiotic classes, are widely used in out-patient clinics and hospitals. The major improvement in developing newer derivatives concerns pharmacokinetic properties. Increased half-lives, persisting concentrations in tissues, interstitial fluids and macrophages confer upon newer macrolides significant
A Bryskier
The Journal of antimicrobial chemotherapy, 41 Suppl B, 1-21 (1998-05-14)
Roxithromycin is a semi-synthetic 14-membered-ring macrolide antibiotic in which the erythronolide A lactone ring has been altered to prevent inactivation in the gastric milieu. The in-vitro activity of roxithromycin is well documented and similar to that of other macrolide antibiotics.
[Roxithromycin--a new macrolide antibiotic].
S V Iakovlev et al.
Terapevticheskii arkhiv, 67(12), 61-66 (1995-01-01)
[New antimicrobial agent series XXXIX: Roxithromycin].
K Hara et al.
The Japanese journal of antibiotics, 44(5), 494-505 (1991-05-01)
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