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Merck

ED2P

Sigma-Aldrich

Ethylenediaminetetraacetic acid dipotassium salt dihydrate

≥98%

Sinónimos:

(Ethylenedinitrilo)tetraacetic acid dipotassium salt, Dipotassium ethylenediaminetetraacetate dihydrate, EDTA dipotassium salt, Edathamil, Potassium ethylenediaminetetraacetate dibasic

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About This Item

Fórmula lineal:
HOOCCH2(KOOCCH2)NCH2CH2N(CH2COOK)CH2COOH · 2H2O
Número de CAS:
Peso molecular:
404.45
EC Number:
UNSPSC Code:
12352107
NACRES:
NA.77

biological source

synthetic

Quality Level

assay

≥98%

form

powder

reaction suitability

reagent type: chelator

pH

4.0-5.0 (25 °C, 40.4 g/L)

mp

255-280 °C (dec.) (lit.)

solubility

3 M KOH: 160 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

room temp

SMILES string

O.O.O.O.[K+].[K+].[K+].[K+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2K.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

JFROQFOCFOKDKU-UHFFFAOYSA-L

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Application

Ethylenediaminetetraacetic acid dipotassium salt dehydrate has been used as a component:
  • of EDTA–glycerol solution (EDTA-G) for decalcification
  • of buffer for monoamine and pterine analysis
  • of T-cell resuspension buffer

Used to eliminate inhibition of enzyme catalyzed reactions due to traces of heavy metals

Biochem/physiol Actions

Ethylenediaminetetraacetic acid (EDTA) is an anticoagulant, majorly used in preventing clotting of blood. EDTA may trigger aggregation of platelets resulting in pseudothrombocytopenia. EDTA-tetracycline therapy decreases coronary artery calcium levels in atherosclerosis. Calcium disodium EDTA administration is effective in slowing down the progression of chronic kidney disease. It also enhances the antimicrobial functionality of lysozyme and improves shelf life of cheese.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Inhalation

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Whole body insulin responsiveness is higher in beef steers selected for increased muscling
McGilchrist P, et al.
Animal : An International Journal of Animal Bioscience, 5(10), 1579-1586 (2011)
A novel decalcification method for adult rodent bone for histological analysis of peripheral-central nervous system connections
Begum F, et al.
Journal of Neuroscience Methods, 187(1), 59-66 (2010)
Cytochrome c oxidase activity is a metabolic checkpoint that regulates cell fate decisions during T cell activation and differentiation
Tarasenko TN, et al.
Cell Metabolism, 25(6), 1254-1268 (2017)
Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term chemotherapy
Maniscalco BS and Taylor KA
Pathophysiology : The Official Journal of the International Society for Pathophysiology / ISP, 11(2), 95-101 (2004)
Comparison of the efficacy of ethylenediaminetetraacetic acid and tetracycline hydrochloride as root conditioning agents: An in vitro study
Nanda T, et al.
Journal of the International Clinical Dental Research Organization, 4(1), 2-2 (2012)

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