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C0694990

Cefuroxime Axetil

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

[6R-[6α,7β(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester

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About This Item

Fórmula empírica (notación de Hill):
C20H22N4O10S
Número de CAS:
64544-07-6
Peso molecular:
510.47
MDL number:
MFCD00864991
UNSPSC Code:
41116107
PubChem Substance ID:
329774816
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

cefuroxime

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1[C@@H](NC(/C(C2=CC=CO2)=N\OC)=O)[C@]3([H])N1C(C(OC(C)OC(C)=O)=O)=C(COC(N)=O)CS3

InChI

1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1

InChI key

KEJCWVGMRLCZQQ-YJBYXUATSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cefuroxime Axetil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Related product

Referencia del producto
Descripción
Precios

1098209

Cefuroxime sodium, United States Pharmacopeia (USP) Reference Standard

1098220

Cefuroxime Axetil, United States Pharmacopeia (USP) Reference Standard

1098231

Cefuroxime Axetil Delta-3-Isomers, United States Pharmacopeia (USP) Reference Standard

C0695000

Cefuroxime sodium, European Pharmacopoeia (EP) Reference Standard

1098253

Cefuroxime Axetil E-isomers, United States Pharmacopeia (USP) Reference Standard

BP502

Cefuroxime Axetil, British Pharmacopoeia (BP) Reference Standard

BP925

Cefuroxime sodium, British Pharmacopoeia (BP) Reference Standard

PHR2683

Cefuroxime Sodium, certified reference material, pharmaceutical secondary standard

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Sruti Jammula et al.
Drug delivery, 22(1), 125-135 (2014-01-15)
Biphasic floating minitablets of cefuroxime axetil were prepared by melt granulation technique using two different grades of gelucire namely 50/13 and 43/01 to maintain constant plasma drug concentration. Loading dose of cefuroxime axetil was formulated as immediate release (IR) minitablets
M A Marx et al.
Drug intelligence & clinical pharmacy, 22(9), 651-658 (1988-09-01)
Cefuroxime axetil is a orally active prodrug formulation of cefuroxime, which upon absorption undergoes immediate deesterification to free cefuroxime. Cefuroxime axetil offers an in vitro antibacterial spectrum against many gram-positive and some gram-negative organisms. Its beta-lactamase stability makes it useful
J F Westphal
Revue de laryngologie - otologie - rhinologie, 111(5), 503-505 (1990-01-01)
Cefuroxime axetil (C.A.E.) is a broad spectrum cephalosporin, suitable for oral route. Its antibacterial activity includes all the pathogens usually responsible for E.N.T. infection, with low M.I.C.'s: H. influenzae, S. pneumoniae, S. aureus, S. pyogene. The stability of the drug
[Oral cephalosporins. Role of cefuroxime-axetil].
E Bergogne-Berezin
Therapie, 43 Suppl 4, 343-349 (1988-06-01)
L J Scott et al.
Drugs, 61(10), 1455-1500 (2001-09-18)
Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, has proven in vitro antibacterial activity against several gram-positive and gram-negative organisms, including those most frequently associated with various common community-acquired infections. In numerous randomised, controlled trials, 5 to 10 days' treatment
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