410225

Glicina

≥98.5%, for peptide synthesis

• Sinónimos: Glicocola, Ácido aminoacético, Ácido aminoetanoico
• Fórmula lineal: NH₂CH₂COOH
• Número de CAS: 56-40-6
• Peso molecular: 75.07
• Beilstein/REAXYS Number: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24865701
• NACRES: NA.21

Propiedades

• product name: Glicina, ACS reagent, ≥98.5%
• grade: ACS reagent
• Quality Level: 200
• assay: ≥98.5%
• form: powder, crystals or granules
• impurities: H₂SO₄, passes test (darkened); Hydrolyzable subsances, passes test
• ign. residue: ≤0.1%
• color: white
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• anion traces: chloride (Cl^-): ≤0.005%; sulfate (SO₄^2-): ≤0.005%
• cation traces: NH₄⁺: ≤0.005%; heavy metals: ≤0.002% (by ICP)
• application(s): peptide synthesis
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Descripción

General description

Glycine is the simplest amino acid building block.

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Neurotransmisor inhibidor de la médula espinal, regulador alostérico de los receptores NMDA.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)