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Sulfadoxina

VETRANAL®, analytical standard

Sinónimos:

4-amino-N-(5,6-dimetoxi-4-pirimidinil)benzenosulfamida, Sulfadoxina

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About This Item

Fórmula empírica (notación de Hill):
C12H14N4O4S
Número de CAS:
2447-57-6
Peso molecular:
310.33
Beilstein/REAXYS Number:
625453
EC Number:
219-504-9
MDL number:
MFCD00792890
UNSPSC Code:
41116107
PubChem Substance ID:
329753909
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC

InChI

1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

PJSFRIWCGOHTNF-UHFFFAOYSA-N

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Categorías relacionadas

General description

Chemical structure: sulfonamide
Sulfadoxin belongs to the long acting group of sulfonamides, which acts by inhibiting dihydropteroate synthase in intracellular sporozoa such as Eimeria and Toxoplasma and Plasmodium.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadoxin may be used as a reference standard for the determination of the analyte in plasma samples using packed-column supercritical fluid chromatography (SFC).

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCK1960
BCCC5858
BCBV7742
BCBS4285V
SZBE045XV

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Determination of sulfadoxine in human blood plasma using packed-column supercritical fluid chromatography.
Bhoir IS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 757(1) (2001)
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Sulfadoxine-pyrimethamine (SP) is used throughout Africa for intermittent preventive treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional differences in the genotypes responsible for SP resistance when mapping recent surveys of dihydrofolate reductase (dhfr) and dihydropteroate
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