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Merck
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Key Documents

MAB3662

Sigma-Aldrich

Anti-TIF1 beta Antibody

ascites fluid, Chemicon®

Sinónimos:

TIF1beta

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

monoclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_005762.2

UniProt accession no.

Q13263

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TRIM28(10155)

Specificity

Recognizes transcriptional intermediary factor 1beta (TIF1beta). The epitope is localized between amino acids 123-834 of mouse TIF1beta. No cross reactivity with TIF1alpha.

Immunogen

Recombinant protein from mouse TIF1b.

Application

Anti-TIF1 beta Antibody is a Mouse Monoclonal Antibody for detection of Transcriptional Intermediary Factor 1 also known as TIF1 beta & has been validated in ELISA, WB, ICC.
Western blot: 1:500-1:5,000

Immunocytochemistry: 1:500-1:5,000

ELISA: 1:500-1:5,000

Optimal working dilutions must be determined by the end user.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.
Whitelaw, NC; Chong, S; Morgan, DK; Nestor, C; Bruxner, TJ; Ashe, A; Lambley, E; Meehan et al.
Genome Biology null
Florence Cammas et al.
Journal of cell science, 115(Pt 17), 3439-3448 (2002-08-03)
The transcriptional intermediary factor 1 (TIF1) family protein TIF1beta is a corepressor for Krüppel-associated box (KRAB)-domain-containing zinc finger proteins and plays a critical role in early embryogenesis. Here, we examined TIF1beta distribution in the nucleus of mouse embryonic carcinoma F9
A L Nielsen et al.
The EMBO journal, 18(22), 6385-6395 (1999-11-24)
Mammalian TIF1alpha and TIF1beta (KAP-1/KRIP-1) are related transcriptional intermediary factors that possess intrinsic silencing activity. TIF1alpha is believed to be a euchromatic target for liganded nuclear receptors, while TIF1beta may serve as a co-repressor for the large family of KRAB
KAP1 controls endogenous retroviruses in embryonic stem cells.
Helen M Rowe,Johan Jakobsson,Daniel Mesnard,Jacques Rougemont,Severine Reynard et al.
Nature null
Andrea Coluccio et al.
Epigenetics & chromatin, 11(1), 7-7 (2018-02-28)
The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control regions (ICRs) during the wave of genome-wide reprogramming that precedes implantation. In naïve murine
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