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Key Documents

MAB1954

Sigma-Aldrich

Anti-Integrin α4 Antibody, clone P4G9

ascites fluid, clone P4G9, Chemicon®

Sinónimos:

CD49d

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

P4G9, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG2bκ

NCBI accession no.

NM_000885.4

UniProt accession no.

P13612

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ITGA4(3676)

Specificity

Human integrin alpha4. The alpha4beta1 integrin receptor recognizes an RGD-independent alternative adhesion site in the CS-1 region of fibronectin.

Application

Detect Integrin α4 using this Anti-Integrin α4 Antibody, clone P4G9 validated for use in IH.
Immunocytochemistry on Jurkat cells at 1:1,600.

Inhibits attachment of hematopoeitic cells and fibroblasts to fibronectin (note: sodium azide should be removed prior to attachment assay).

Optimal working dilutions must be determined by the end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Linkage

Replaces: 04-1131

Storage and Stability

Store at -20 °C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands.
Graham, Kate L, et al.
The Journal of General Virology, 86, 3397-3408 (2005)
Expression of megakaryocytic and erythroid properties in human leukemic cells.
Tani, T, et al.
Experimental Hematology, 24, 158-168 (1996)
Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane.
M Xia, S P Sreedharan, P Dazin, C H Damsky, E J Goetzl
Journal of Cellular Biochemistry null
Fabienne De Toni-Costes et al.
PloS one, 5(3), e9807-e9807 (2010-03-31)
Cell survival mediated by integrin engagement has been implicated in cell adhesion-mediated drug resistance. We have recently demonstrated that the activation of glycogen synthase kinase 3 beta (GSK3beta) is a new pathway supporting the chemoresistance of leukemic cells adhered to
Y L Kapila et al.
The Journal of biological chemistry, 274(43), 30906-30913 (1999-10-16)
Intact fibronectin (FN) protects cells from apoptosis. When FN is fragmented, specific domains induce proteinase expression in fibroblasts. However, it is not known whether specific domains of FN can also regulate apoptosis. We exposed fibroblasts to four recombinant FN fragments
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