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Documentos clave

AB5370

Sigma-Aldrich

Anti-Capsaicin Receptor Antibody, CT

serum, Chemicon®

Sinónimos:

Vanilloid Receptor 1, VR1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clone:
polyclonal
application:
IHC
species reactivity:
rat, human
technique(s):
immunohistochemistry: suitable
citations:
4

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TRPV1(7442)

Specificity

Capsaicin Receptor (Vanilloid Receptor 1, VR1).

Immunogen

A 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
Epitope: C-terminus

Application

Detect Capsaicin Receptor using this Anti-Capsaicin Receptor Antibody, C-terminus validated for use in IH.
Immunohistochemistry: 1:2,000. The antibody reacts well with tissue from the rat dorsal root ganglia.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neuroinflammation & Pain

Neurotransmitters & Receptors

Physical form

Serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.

Storage and Stability

Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Emily M Besecker et al.
Experimental neurology, 323, 113092-113092 (2019-11-08)
Dramatic impairment of gastrointestinal (GI) function accompanies high-thoracic spinal cord injury (T3-SCI). The vagus nerve contains mechano- and chemosensory fibers as well as the motor fibers necessary for the central nervous system (CNS) control of GI reflexes. Cell bodies for
Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.
Wallace K MacNaughton, Marja D Van Sickle, Catherine M Keenan, Kelly Cushing, Ken Mackie et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology null
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
De Schepper, HU; De Man, JG; Ruyssers, NE; Deiteren, A; Van Nassauw, L; Timmermans et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation.
G Zacharova, J Palecek, G Zacharova, J Palecek, G Zacharova, J Palecek
Physiological Research null
H U De Schepper et al.
The Journal of physiology, 586(21), 5247-5258 (2008-08-30)
Patients with inflammatory bowel disease often suffer from gastrointestinal motility and sensitivity disorders. The aim of the current study was to investigate the role of transient receptor potential of the vanilloid type 1 (TRPV1) receptors in the pathophysiology of colitis-induced

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