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AB1572

Sigma-Aldrich

Anti-GABA Transporter-2 Antibody

Chemicon®, from rabbit

Sinónimos:

GAT-2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_016615.2

UniProt accession no.

Q9NSD5

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Slc6A13(14412)
rat ... Slc6A13(171163)

Specificity

GABA Transporter-2 (GAT-2), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Immunogen

GAT-2, C-terminus (aa 593-602)

Application

Immunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed tissue.

It is recommended that the antibody is diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1572 has been used for light microscopic studies of the rat nervous system.

Western blot: It has been reported that this antibody works for Western blot (Conti, 1999).

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-GABA Transporter-2 Antibody is validated for use in IH, WB for the detection of GABA Transporter-2.

Physical form

Affinity purified antibody. Purified in PBS with 0.1% sodium azide.

Storage and Stability

Maintain lyophilized material at 2-8°C for up to 12 months. Maintain reconstituted material at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with progressive ataxia that affects both the peripheral and central nervous system (CNS). While later CNS neuropathology involves loss of large principal neurons and glutamatergic and GABAergic synaptic terminals in the
Maria Elisa Calcagnotto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7596-7605 (2002-08-28)
Children with brain malformations often exhibit an intractable form of epilepsy. Although alterations in cellular physiology and abnormal histology associated with brain malformations has been studied extensively, synaptic function in malformed brain regions remains poorly understood. We used an animal
J Johnson et al.
The Journal of comparative neurology, 375(2), 212-224 (1996-11-11)
gamma-Aminobutyric acid (GABA) plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. The distribution and cellular localization of GAT-1, GAT-2, and GAT-3 in the rat retina have been evaluated by using affinity-purified polyclonal antibodies directed

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