8.52229

Fmoc-Thr(Ac₃AcNH-α-Gal)-OH

Novabiochem^®

• Sinónimos: Fmoc-Thr(Ac₃AcNH-α-Gal)-OH, N-α-Fmoc-O-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-threonine
• Fórmula empírica (notación de Hill): C₃₃H₃₈N₂O₁₃
• Número de CAS: 116783-35-8
• Peso molecular: 670.66
• MDL number: MFCD00171374
• UNSPSC Code: 12352209

Propiedades

• Quality Level: 200
• product line: Novabiochem^®
• assay: ≥95% (TLC); ≥95.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 15-25°C
• InChI: 1S/C33H38N2O13/c1-16(27(31(40)41)35-33(42)44-14-25-23-12-8-6-10-21(23)22-11-7-9-13-24(22)25)45-32-28(34-17(2)36)30(47-20(5)39)29(46-19(4)38)26(48-32)15-43-18(3)37/h6-13,16,25-30,32H,14-15H2,1-5H3,(H,34,36)(H,35,42)(H,40,41)/t16-,26-,27+,28-,29+,30-,32+/m1/s1
• InChI key: OXLCJWGAUPPZQJ-ZNHCDWFHSA-N

Descripción

General description

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA ^[1], making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. Removal of the acetyl protecting groups is best carried out by treatment of the peptidyl resin with methanolic ammonia prior to cleavage.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Peptides containing Post-Translational Modifications

Literature references

^[1] J. Kihlberg in ′Fmoc solid phase peptide synthesis: a practical approach′, W.C. Chan & P.D. White (Eds.), Oxford University Press, Oxford, 2000, pp. 195.

Linkage

Replaces: 04-12-8104

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Identity (NMR, 1H): passes test
Identity (NMR): passes test
NMR-spectrum: passes test

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable