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Key Documents

528240

Sigma-Aldrich

Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

form

liquid

Quality Level

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−70°C

General description

Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl2, 50% glycerol, ≤0.1% sodium azide, pH 7.4.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.

Other Notes

Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002.
Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


Certificados de análisis (COA)

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