5.08015

CTOP

• Sinónimos: CTOP, µ Opioid Receptor Antagonist, CTOP
• Fórmula empírica (notación de Hill): C₅₀H₆₇N₁₁O₁₁S₂
• Número de CAS: 103429-31-8
• Peso molecular: 1062.26
• MDL number: MFCD00076708
• UNSPSC Code: 12352200

Propiedades

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.96 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: soluble
• storage temp.: −20°C
• InChI: 1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
• InChI key: PZWWYAHWHHNCHO-UHFFFAOYSA-N

Descripción

General description

A potent antagonist highly selective for µ opioid receptor (K_i = 0.96 nM for µ receptor and >10,000 nM for δ receptors). Often used for studying the functional roles of µ opioid receptors in both central and peripheral nervous systems.

Biochem/physiol Actions

Primary Target
mu opioid

Warning

Toxicity: Standard Handling (A)

Sequence

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Orn: ornithine; Pen: penicillamine; SS bond: 2-7)

Physical form

Supplied as trifluoracetate salt

Other Notes

Feng, Y., et al. 2012. Curr Drug Targets.13, 230.
Hawkins, N., et al. 1989. J. Pharmacol. Exp. Ther.248, 73.
Gulya, K., et al. 1988. Eur. J. Pharmacol.150, 355.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable