444218

MMP-3 Inhibitor I

The MMP-3 Inhibitor I controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: MMP-3 Inhibitor I, Ac-RCGVPD-NH₂, Stromelysin-1 Inhibitor
• Fórmula empírica (notación de Hill): C₂₇H₄₆N₁₀O₉S
• Peso molecular: 686.78
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

Inhibits matrix metalloproteinase-3 (stromelysin) (IC₅₀ = 5 µM). The inhibitor is based on a segment from the conserved region of the NH₂-terminal propeptide domain.

Inhibits the matrix metalloproteinase MMP-3 (IC₅₀ = 5 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-3

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM against MMP-3

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Arg-Cys-Gly-Val-Pro-Asp-NH₂

Physical form

Supplied as a trifluroacetate salt.

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.

Other Notes

Fotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
Hanglow, A.C., et al. 1993. Agents Actions 39, C148.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable