264156-M

Caspase-3 Inhibitor II

InSolution

• Sinónimos: InSolution Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
• Fórmula empírica (notación de Hill): C₃₀H₄₁FN₄O₁₂
• Peso molecular: 668.66
• UNSPSC Code: 12352200

Propiedades

• form: solution
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: clear very faintly yellow
• storage temp.: −20°C

Descripción

General description

A potent, cell-permeable, and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

Biochem/physiol Actions

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Warning

Toxicity: Irritant (B)

Sequence

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Physical form

A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264155) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

single spot by TLC

Other Notes

Nicholson, D.W. 1996. Nat. Biotechnol.14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841.0
Nicholson, D.W., et al. 1995. Nature376, 37.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 188.6 °F - (refers to pure substance)
• flash_point_c: 87 °C - (refers to pure substance)