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Merck
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Documentos clave

23-056-M

Sigma-Aldrich

XIAP, active

Sinónimos:

Baculoviral IAP repeat-containing protein 4 (BIRC4), IAP-like protein, Inhibitor of apoptosis protein 3 (API3)

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About This Item

UNSPSC Code:
12352204
eCl@ss:
32160405
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

Quality Level

100

form

liquid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_001167

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Este artículo
N350N100N2
vibrant-m

N4000

General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified

vibrant-m

N350

General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified

vibrant-m

N100

General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified

vibrant-m

N2

General Purpose Viscosity Standard; UKAS ISO/IEC17025 and ISO 17034 certified

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

manufacturer/tradename

Paragon Scientific Ltd

manufacturer/tradename

Paragon Scientific Ltd

manufacturer/tradename

Paragon Scientific Ltd

manufacturer/tradename

Paragon Scientific Ltd

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

viscosity

10030 mPa.s(25 °C)

viscosity

717.4 mPa.s(25 °C)

viscosity

202.6 mPa.s(25 °C)

viscosity

2.144 mPa.s(25 °C)

General description

X-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.

Application

Ubiquitination Cascade Comoponent: E3

Physical form

Purified using glutathione sepharose, followed by gel filtration

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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