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Merck
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Documentos clave

124005

Sigma-Aldrich

Akt Inhibitor

The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinónimos:

Akt Inhibitor, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl- sn-glycerocarbonate, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate

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About This Item

Fórmula empírica (notación de Hill):
C30H58O10
Peso molecular:
578.78
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to off-white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.

Biochem/physiol Actions

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 5.0 µM for Akt (PKB)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Use anhydrous DMSO for reconstitution.

Other Notes

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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