04-1470

Anti-OX40L (CD252) Antibody, clone RM134L

clone RM134L, from rat

• Sinónimos: Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: rat
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: RM134L, monoclonal
• species reactivity: mouse
• technique(s): flow cytometry: suitable; immunohistochemistry: suitable
• isotype: IgG2bκ
• NCBI accession no.: NP_033478
• UniProt accession no.: P43488
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Tnfsf4(22164)

Descripción

General description

OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.

Specificity

This antibody recognizes the extracellular domain of OX40L.

Immunogen

Mouse OX40L cDNA-transfected NRK cells

Application

Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)

Quality

Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.

Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.

Target description

22 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Mouse OX40L/L5178Y cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable