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890000P

Avanti

MVL5

Avanti Research™ - A Croda Brand 890000P, powder

Sinónimos:

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

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About This Item

Fórmula empírica (notación de Hill):
C59H116Cl5N7O4
Número de CAS:
464926-03-2
Peso molecular:
1164.86
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

package of 1 × 1 mg (890000P-1mg)
package of 1 × 5 mg (890000P-5MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890000P

application(s)

advanced drug delivery

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCC/C=C\CCCCCCCCOC1=C(OCCCCCCCC/C=C\CCCCCCCC)C=C(C(NCCNC(C([NH2+]CCC[NH3+])CCC[N+](CCC[NH3+])([H])CCC[NH3+])=O)=O)C=C1.[5Cl-]

Application

MVL5 has been used in liposome preparation.

Biochem/physiol Actions

MVL5 is a cationic lipid and is a pentavalent molecule. It is combined with 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOPC) in liposome formulation, for efficient gene transfection. It is considered less toxic.

Packaging

5 mL Amber Glass Screw Cap Vial (890000P-1MG)
5 mL Amber Glass Screw Cap Vial (890000P-5MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Chia-Ling Chan et al.
The journal of gene medicine, 16(3-4), 84-96 (2014-04-23)
Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential application in gene therapy. A key challenge in creating CL-DNA complexes for application is that their transfection efficiency (TE) is adversely affected by serum. In particular, little is known
Polyamine Drug Discovery, 226-226 (2012)
Kai Ewert et al.
Journal of medicinal chemistry, 45(23), 5023-5029 (2002-11-01)
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper describes the efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for
Asymmetric cationic liposomes designed for heat-activated association with cells
Jing Y, et al.
Colloids and Surfaces. B, Biointerfaces, 151, 112-118 (2017)
Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid
Chan CL, et al.
Biomaterials, 33(19), 4928-4935 (2012)
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