857128P

18:0 Lyso PA

Avanti Research^™ - A Croda Brand

• Sinónimos: 1-octadecanoyl-sn-glycero-3-phosphate (sodium salt); stearoyl lysophosphatidic acid; PA(18:0/0:0); 18:0 LPA; s-LPA; 110680
• Fórmula empírica (notación de Hill): C₂₁H₄₂O₇PNa
• Número de CAS: 325465-92-7
• Peso molecular: 460.52
• UNSPSC Code: 51191904
• NACRES: NA.25

Propiedades

• description: 1-stearoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
• assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• form: powder
• packaging: pkg of 1 × 25 mg (857128P-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
• InChI key: YJQFVAZHPIBPHN-VEIFNGETSA-M

Descripción

General description

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells. 18:0 Lyso PA has stearic acid at sn-1 and a hydroxyl group at sn-2 position.

Application

18:0 Lyso PA is suitable for use:

• to determine the extraction recovery of LPA at neutral pH and acidic pH by chromatographic method
• to use as internal standard to study the role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis
• to investigate its effects on clathrin?dependent endocytosis

Biochem/physiol Actions

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Packaging

5 mL Amber Glass Screw Cap Vial (857128P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3