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850446C

Avanti

14:0-18:0 PC

1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, chloroform

Sinónimos:

1-tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine; MSPC; PC(14:0/18:0)

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About This Item

Fórmula empírica (notación de Hill):
C40H80NO8P
Número de CAS:
76343-22-1
Peso molecular:
734.04
UNSPSC Code:
51191904
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850446C-25mg)
pkg of 2 × 4 mL (850446C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850446C

concentration

10 mg/mL (850446C-25mg)
25 mg/mL (850446C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41(3,4)5)36-46-39(42)32-30-28-26-24-22-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

InChI key

TYAQXZHDAGZOEO-KXQOOQHDSA-N

General description

Phosphatidylcholine (PC) is one of the most important constituent of colon′s mucosal layer. 14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) is an asymmetrical lipid.

Application

14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) may be used:
  • in lipid bilayers to study its miscibility with d-erythro-N-palmitoyl-sphingomyelin (16:0-SM) using differential scanning calorimetry (DSC)
  • as an asymmetrical lipid in liposomes to study the impact of bilayer area and lipid geometry on the design of liposomes as liposomal solubilizing agents
  • to prepare a low temperature-sensitive liposome encapsulating thrombolytics to assess thrombolytic activity following hyperthermia

Biochem/physiol Actions

Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.

Packaging

5 mL Clear Glass Sealed Ampule (850446C-200mg)
5 mL Clear Glass Sealed Ampule (850446C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Journal of controlled release : official journal of the Controlled Release Society, 319, 222-233 (2020-01-01)
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Van Du Nguyen et al.
ACS applied materials & interfaces, 12(9), 10130-10141 (2020-02-12)
Although great efforts have been undertaken to develop a nanoparticle-based drug delivery system (DDS) for the treatment of solid tumors, the therapeutic outcomes are still limited. Immune cells, which possess an intrinsic ability to phagocytose nanoparticles and are recruited by
Bohdana Térová et al.
Biochimica et biophysica acta, 1667(2), 182-189 (2004-12-08)
In this study we have used differential scanning calorimetry (DSC) to study the miscibility of different saturated phosphatidylcholines (PCs) with D-erythro-N-palmitoyl-sphingomyelin (16:0-SM). Information about the miscibility was obtained by observing the thermotropic phase behavior of binary mixtures of saturated PCs
Li-Juan Zhao et al.
Journal of ethnopharmacology, 260, 112943-112943 (2020-05-19)
Arenobufagin (ArBu) is an important anti-tumor ingredient of Chan'su which has long been used as traditional Chinese medicine in clinic for tumor therapy in China. The purpose of our study is to investigate the lipid homeostasis regulation effects of ArBu
Simon Becher et al.
Analytical chemistry, 90(19), 11486-11494 (2018-09-11)
Phosphatidylcholines are the major phospholipid component of most eukaryotic cell membranes. Phosphatidylcholines have been shown to actively participate in regulatory and metabolic processes. Dysfunctional metabolic processes have been linked to human disease and can result in altered phosphatidylcholine structural features

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