840521P

18:1 Lysyl PG

1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (chloride salt), powder

• Sinónimos: Lysyl-DOPG
• Fórmula empírica (notación de Hill): C₄₈H₉₃Cl₂N₂O₁₁P
• Número de CAS: 1246303-07-0
• Peso molecular: 976.14
• UNSPSC Code: 51191904
• NACRES: NA.25

Propiedades

• assay: >99% (up to 15% acyl migration on lysine, TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (840521P-1mg); pkg of 1 × 10 mg (840521P-10mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 840521P
• lipid type: phospholipids; bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC(COC([C@@](CCCC[NH3+])([H])[NH3+])=O)COP(O)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-].[Cl-]
• InChI: 1S/C48H91N2O11P.2ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36-46(52)57-41-44(42-60-62(55,56)59-40-43(51)39-58-48(54)45(50)35-33-34-38-49)61-47(53)37-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;;/h17-20,43-45,51H,3-16,21-42,49-50H2,1-2H3,(H,55,56);2*
• InChI key: QLNZUMYQGKEYKU-CIZZXKMDSA-N

Descripción

General description

18:1 Lysyl PG/1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (lysyl-DOPG) is a synthetic phospholipid. It has a lysine group, added to the terminal glycerol of DOPG. Lysyl-phosphatidylglycerol (LPG), a membrane lipid is mainly seen in gram-positive bacteria. It is cationic phospholipid.

Application

18:1 Lysyl PG is suitable to prepare liposome solutions.

Biochem/physiol Actions

Lysyl-phosphatidylglycerol (lysyl-PG) in the cytoplasmic membranes of Staphylococcus is associated with improved resistance to antibiotics, like daptomycin and host defense antimicrobial peptides.

Packaging

5 mL Amber Glass Screw Cap Vial (840521P-1mg)

5 mL Clear Glass Sealed Ampule (840521P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids