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Merck

840521P

Avanti

18:1 Lysyl PG

1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (chloride salt), powder

Sinónimos:

Lysyl-DOPG

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About This Item

Fórmula empírica (notación de Hill):
C48H93Cl2N2O11P
Número de CAS:
Peso molecular:
976.14
UNSPSC Code:
51191904
NACRES:
NA.25

assay

>99% (up to 15% acyl migration on lysine, TLC)

form

powder

packaging

pkg of 1 × 1 mg (840521P-1mg)
pkg of 1 × 10 mg (840521P-10mg)

manufacturer/tradename

Avanti Research - A Croda Brand 840521P

lipid type

phospholipids
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC(COC([C@@](CCCC[NH3+])([H])[NH3+])=O)COP(O)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-].[Cl-]

General description

18:1 Lysyl PG/1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (lysyl-DOPG) is a synthetic phospholipid. It has a lysine group, added to the terminal glycerol of DOPG. Lysyl-phosphatidylglycerol (LPG), a membrane lipid is mainly seen in gram-positive bacteria. It is cationic phospholipid.

Application

18:1 Lysyl PG is suitable to prepare liposome solutions.

Biochem/physiol Actions

Lysyl-phosphatidylglycerol (lysyl-PG) in the cytoplasmic membranes of Staphylococcus is associated with improved resistance to antibiotics, like daptomycin and host defense antimicrobial peptides.

Packaging

5 mL Amber Glass Screw Cap Vial (840521P-1mg)
5 mL Clear Glass Sealed Ampule (840521P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance
Kilelee E, et al.
Antimicrobial Agents and Chemotherapy, 54(10), 4476-4479 (2010)
Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide
Williamson JA, et al.
Journal of molecular biology, 393(2), 383-396 (2009)
The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions
Sohlenkamp C, et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007)
Christian Sohlenkamp et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007-11-06)
Lysyl-phosphatidylglycerol (LPG) is a well-known membrane lipid in several gram-positive bacteria but is almost unheard of in gram-negative bacteria. In Staphylococcus aureus, the gene product of mprF is responsible for LPG formation. Low pH-inducible genes, termed IpiA, have been identified
Lipid bilayer modules as determinants of K+ channel gating
Syeda R, et al.
Test, 289(7), 4233-4243 (2014)

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