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840514P

Avanti

16:0-18:1 Phosphatidylethanol

Avanti Research™ - A Croda Brand 840514P, powder

Sinónimos:

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (sodium salt)

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About This Item

Fórmula empírica (notación de Hill):
C39H74NaO8P
Número de CAS:
322647-55-2
Peso molecular:
724.96
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 2 × 100 mg (840514P-200mg)
pkg of 1 × 25 mg (840514P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840514P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

General description

Phosphatidylethanol (PEth) is a phospholipid, that is generated in the presence of ethanol in cell membranes. PEths like PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 possesses a common phosphoethanol head. Two fatty acid chains of variable length and degree of saturation are bound to this head group.
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%.

Application

16:0-18:1 Phosphatidylethanol may be used in surface planar bilayers (SPBs) formation.

Biochem/physiol Actions

Phosphatidylethanols (PEths) serves as crucial biomarkers of alcohol consumption.

Packaging

5 mL Clear Glass Sealed Ampule (840514P-200mg)
5 mL Clear Glass Sealed Ampule (840514P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Surface planar bilayers of phospholipids used in protein membrane reconstitution: an atomic force microscopy study
Domenech O, et al.
Colloids and Surfaces. B, Biointerfaces, 47(1), 102-106 (2006)
Anders Isaksson et al.
Drug testing and analysis, 3(4), 195-200 (2011-03-26)
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues where ethanol by phospholipase D has been bound at the position that normally contains an amino-alcohol. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as
Alexandra Schröck et al.
Bioanalysis, 6(17), 2285-2294 (2014-11-11)
For early diagnosis and therapy of alcohol-related disorders, alcohol biomarkers are highly valuable. Concerning specificity, indirect markers can be influenced by nonethanol-related factors, whereas direct markers are only formed after ethanol consumption. Sensitivity of the direct markers depends on cut-offs
David Wensbo Posaric et al.
Analytical and bioanalytical chemistry, 406(19), 4735-4744 (2014-05-29)
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-PEths), lyso-PEth-16:0, and penta-deuterium-labeled PEth analogs (d5-PEths), were synthesized by enzyme-independent synthetic routes. A general solvent system consisting of a mixture of acetone-d6 and methanol-d4 (97:3; v/v) was found to provide
The detection of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol and ethyl glucuronide in human umbilical cord
Jones J, et al.
American Journal of Analytical Chemistry, 3(12), 800-800 (2012)
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