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791275P

Avanti

18:0 PE-DTPA (Gd)

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder

Sinónimos:

1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt); DSPE-DTPA (Gd)

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About This Item

Fórmula empírica (notación de Hill):
C55H106GdN6O17P
Número de CAS:
2260795-19-3
Peso molecular:
1311.68
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (791275P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 791275P

shipped in

dry ice

storage temp.

−20°C

Categorías relacionadas

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.

Application

18:0 PE-DTPA (Gd) has been used:
  • as a component of Gadolinium-liposome preparation
  • in the nanodics preparation for nuclear magnetic resonance (NMR) studies
  • in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
  • as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.

Packaging

5 mL Amber Glass Screw Cap Vial (791275P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
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