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Key Documents

780201C

Avanti

18:1 PE MCC

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

Sinónimos:

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

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About This Item

Fórmula empírica (notación de Hill):
C53H90N2NaO11P
Número de CAS:
384847-49-8
Peso molecular:
985.25
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (780201C-25mg)

manufacturer/tradename

Avanti Polar Lipids 780201C

concentration

10 mg/mL (780201C-25mg)

shipped in

dry ice

storage temp.

−20°C

Categorías relacionadas

General description

18:1 PE MCC (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide]) lipid comprising of phosphoethanolamine linked to two oleic acid via its phosphate group and to a maleimide group via its amino group. It is a maleimide-functionalized thiol-reactive lipid.

Application

18:1 PE MCC 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] has been used:
  • in liposome preparation for cysteine coupling studies
  • in nanodisc impregnation for ras sarcoma protein (K-RAS4B) tethering
  • in liposome preparation for single molecule imaging

Packaging

5 mL Clear Glass Sealed Ampule (780201C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Liposome-based assays to study membrane-associated protein networks
Methods in Enzymology, 534, 223-243 (2014)
Walter Huynh et al.
The Journal of cell biology, 216(10), 3051-3060 (2017-09-09)
Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored

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