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Documentos clave

700146P

Avanti

alkyne-cholesterol

27-norcholest-5-en-25-yn-3β-ol, powder

Sinónimos:

alkynyl cholesterol

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About This Item

Fórmula empírica (notación de Hill):
C26H40O
Número de CAS:
1631985-09-5
Peso molecular:
368.60
MDL number:
MFCD32706892
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (700146P-100ug)
pkg of 1 × 250 μg (700146P-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700146P

lipid type

click reagents

shipped in

dry ice

storage temp.

−20°C

Categorías relacionadas

General description

Alkyne-cholesterol is a clickable cholesterol probe proprietary for Avanti Polar Lipids. They differ from cholesterol by having an alkyne group.
This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry′, in the presence of a copper (Cu)-containing catalyst.

Biochem/physiol Actions

Alkyne-cholesterol is not applicable for use in living cells due to copper ion (Cu (I) and Cu (II)) requirements. It aids in easy and sensitive detection of cholesterol using various biophysical methods. Alkyne-cholesterol can be conjugated to boron-dipyrromethene (BODIPY) fluorescent dye. It is useful in cholesterol trafficking studies in various organelles including mitochondria, endoplasmic reticulum and Golgi.

Packaging

5 mL Amber Glass Screw Cap Vial (700146P-100ug)
5 mL Amber Glass Screw Cap Vial (700146P-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

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Katherine Windsor et al.
Journal of lipid research, 54(10), 2842-2850 (2013-07-06)
Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available. We present a strategy to identify protein-reactive lipids and apply it to a
J Králová et al.
Folia biologica, 65(1), 1-10 (2019-06-07)
Cellular cholesterol plays fundamental and diverse roles in many biological processes and affects the pathology of various diseases. Comprehensive and detailed understanding of the cellular functions and characteristics of cholesterol requires visualization of its subcellular distribution, which can be achieved

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