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D218200

Sigma-Aldrich

Ácido 5,5′-ditiobis(2-nitrobenzoico)

ReagentPlus®, 99%

Sinónimos:

DTNB, Disulfuro de 3-carboxi-4-nitrofenilo, Disulfuro de bis(3-carboxi-4-nitrofenilo), Reactivo de Ellman, Ácido 6,6′-dinitro-3,3′-ditiodibenzoico

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About This Item

Fórmula lineal:
[-SC6H3(NO2)CO2H]2
Número de CAS:
69-78-3
Peso molecular:
396.35
Beilstein/REAXYS Number:
1896821
EC Number:
200-714-4
MDL number:
MFCD00007140
UNSPSC Code:
12352100
PubChem Substance ID:
24893651
NACRES:
NA.22

Quality Level

200

product line

ReagentPlus®

assay

99%

form

powder

mp

240-245 °C (dec.) (lit.)

SMILES string

OC(=O)c1cc(SSc2ccc(c(c2)C(O)=O)[N+]([O-])=O)ccc1[N+]([O-])=O

InChI

1S/C14H8N2O8S2/c17-13(18)9-5-7(1-3-11(9)15(21)22)25-26-8-2-4-12(16(23)24)10(6-8)14(19)20/h1-6H,(H,17,18)(H,19,20)

InChI key

KIUMMUBSPKGMOY-UHFFFAOYSA-N

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General description

DTNB (Ellman’s reagent) is commonly used for quantification of sulfhydryl (thiol) groups in proteins and biomolecules.

Application

5,5′-Dithiobis(2-nitrobenzoic acid) is a water soluble reagent mainly used for the derivatization of sulfhydryl groups.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
STBJ6791
STBG6026V
STBG1024V
STBD3094V
MKBK7085V

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Structure (London, England : 1993), 16(5), 695-704 (2008-05-09)
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Staphylococcus aureus can induce platelet aggregation. The rapidity and degree of this correlates with the severity of disseminated intravascular coagulation, and depends on platelet peptidoglycans. Surface-located thiol isomerases play an important role in platelet activation. The staphylococcal extracellular adherence protein
Atef M K Nassar et al.
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Exposure to the nerve agent soman is difficult to treat due to the rapid dealkylation of the soman-acetylcholinesterase (AChE) conjugate known as aging. Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against soman, while the efficacy of
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