936499

3-Pyridinecarboxylic acid, 6-[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-

≥95%

• Sinónimos: 6-[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]-3-pyridinecarboxylic acid
• Fórmula empírica (notación de Hill): C₂₃H₂₁N₅O₆
• Número de CAS: 2633591-27-0
• Peso molecular: 463.44
• Código UNSPSC: 12352106
• NACRES: NA.22

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95%
• Formulario: powder or crystals
• color: light yellow to dark yellow
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(O)C1=CN=C(C=C1)N2CCN(C3=CC=C4C(=O)N(C(=O)C4=C3)C5C(=O)NC(=O)CC5)CC2
• InChI: 1S/C23H21N5O6/c29-19-6-4-17(20(30)25-19)28-21(31)15-3-2-14(11-16(15)22(28)32)26-7-9-27(10-8-26)18-5-1-13(12-24-18)23(33)34/h1-3,5,11-12,17H,4,6-10H2,(H,33,34)(H,25,29,30)
• Clave InChI: MZYKMQYHJGPMEI-UHFFFAOYSA-N

Descripción

Aplicación

This is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Otras notas

1. Targeted Protein Degradation by Small Molecules
2. Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
3. Small-Molecule PROTACS: New Approaches to Protein Degradation
4. Targeted Protein Degradation: from Chemical Biology to Drug Discovery
5. Impact of linker length on the activity of PROTACs

Información legal

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable