933732

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average M_n 5,000, PEI average M_n 5,000

• Sinónimos: PEG-b-PEI, PEG-PEI, Poly(ethylene glycol)-block-polyethylenimine
• Fórmula lineal: CH₃(C₂H₄O)_n(C₂H₅N)_mOH
• UNSPSC Code: 12352207

Propiedades

• form: powder and chunks
• Quality Level: 100
• mol wt: PEG M_n 5,000 Da; PEG average M_n 5,000; PEI M_n 5,000 Da; PEI average M_n 5,000
• color: white to pale yellow
• storage temp.: 2-8°C

Descripción

Application

Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable