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779229

Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Sinónimos:

Cavasol® W8 HP, HGC

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About This Item

Número de CAS:
128446-34-4
UNSPSC Code:
12352201
NACRES:
NA.22

grade

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Quality Level

200

form

powder

extent of labeling

0.5-0.7 molar substitution

impurities

≤0.1% propylene glycol (Ph Eur)

loss

≤10.0% loss on drying

pH

6-9 (2% in H2O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

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General description

(2-Hydroxypropyl)-γ-cyclodextrin (HP-β-CD) is a hydrophilic compound that can be used as a complexing agent to increase the aqueous solubility and dissolution rate of the drug molecule.

Application

For R&D use
HP-β-CD can be utilized to improve the aqueous solubility and dissolution rate of zolpidem (ZP) upon complexation. ZP-HP-β-CD complexes showed improved ataxic activity.
It is also used to enhance the wound healing property of curcumin by increasing the water solubility.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Complexation of Zolpidem with 2-hydroxypropyl-β -, methyl-β -, and 2-hydroxypropyl-γ -cyclodextrin: Effect on aqueous solubility, dissolution rate, and ataxic activity in rat
Trapani, G, et al.
Journal of Pharmaceutical Sciences, 89(11), 1443-1451 (2000)
Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-γ -cyclodextrin inclusion complex
Macedo OFL, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 86(11), 101-106 (2012)
Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film
Wathoni N, et al.
International Journal of Biological Macromolecules, 98(11), 268-276 (2017)
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown

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