415294

5-Iodo-1,3-dimethyluracil

99%

• Fórmula empírica (notación de Hill): C₆H₇IN₂O₂
• Número de CAS: 40738-83-8
• Peso molecular: 266.04
• MDL number: MFCD00192228
• UNSPSC Code: 12352100
• PubChem Substance ID: 24865988
• NACRES: NA.22

Propiedades

• assay: 99%
• form: solid
• mp: 225 °C (dec.) (lit.)
• solubility: DMSO: soluble 10 mg/mL(lit.)
• SMILES string: CN1C=C(I)C(=O)N(C)C1=O
• InChI: 1S/C6H7IN2O2/c1-8-3-4(7)5(10)9(2)6(8)11/h3H,1-2H3
• InChI key: XUUVRIXNFFFPCM-UHFFFAOYSA-N

Descripción

General description

The effect of 5-iodo-1,3-dimethyluracil on the incorporation of [¹²⁵I] 5-iodo-2′-deoxyuridine [¹²⁵I radiolabelled IdUrd] in DNA of cancer cells has been studied. Synthesis of 5-iodo-1,3-dimethyluracil from aromatic organomercurials; 5-(acetoxymercurio)-1,3-dimethyluracil or 5,5′-mercuriobis(1,3-dimethyluracil) has been reported.

Application

5-Iodo-1,3-dimethyluracil may be used for the synthesis of N-[2-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)thio]-4-oxo[1]benzothieno[3,2-d]pyrimidin-3(4H)yl]methanesulfonamide.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H317,H334,H361
• pcodes: P202 - P261 - P280 - P301 + P312 - P302 + P352 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges