254916
7,8-Dihydroxy-6-methoxycoumarin
98%
Sinónimos:
Fraxetin
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About This Item
Fórmula empírica (notación de Hill):
C10H8O5
Número de CAS:
Peso molecular:
208.17
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
Productos recomendados
Quality Level
assay
98%
form
powder
mp
230-231 °C (lit.)
SMILES string
COc1cc2C=CC(=O)Oc2c(O)c1O
InChI
1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
InChI key
HAVWRBANWNTOJX-UHFFFAOYSA-N
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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María Francisca Molina-Jiménez et al.
Brain research, 1009(1-2), 9-16 (2004-05-04)
Rotenone-induced apoptosis is considered to contribute to the etiology of Parkinson's disease (PD). We try to prevent the apoptosis induced by rotenone toxicity with 50 microM myricetin, 100 microM fraxetin and 100 microM N-acetylcysteine (NAC) that protect against reactive oxygen
Po-Lin Kuo et al.
Biological & pharmaceutical bulletin, 29(1), 119-124 (2006-01-06)
Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, was investigated for its effects on differentiation of osteoblasts. By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown that fraxetin exhibits a significant induction of differentiation in two human
Francesco Epifano et al.
Mini reviews in medicinal chemistry, 9(11), 1262-1271 (2009-11-26)
Neurodegenerative disorders are a heterogeneous group of diseases and are among the most invaliding syndromes for humans. The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class
María Francisca Molina-Jiménez et al.
Toxicology and applied pharmacology, 209(3), 214-225 (2005-05-21)
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Recently, it has been shown that fraxetin (coumarin) and myricetin (flavonoid) have significant neuroprotective effects against apoptosis induced by rotenone, increase the total glutathione levels in
Phuong Thien Thuong et al.
Biological & pharmaceutical bulletin, 32(9), 1527-1532 (2009-09-02)
Atherosclerosis is main cause of arteriosclerosis. The pivotal role of low-density lipoprotein (LDL) oxidation in atherogenesis suggests antioxidants may help prevent cardiovascular disease. Fraxinus rhynchophylla DENCE (Oleaceae) is a traditional medicinal plant from East Asia. During the course of characterizing
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