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114715

Sigma-Aldrich

Phenylhydrazine hydrochloride

≥99%

Sinónimos:

Phenylhydrazinium chloride

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About This Item

Fórmula lineal:
C6H5NHNH2 · HCl
Número de CAS:
59-88-1
Peso molecular:
144.60
Beilstein/REAXYS Number:
3594958
EC Number:
200-444-7
MDL number:
MFCD00012924
UNSPSC Code:
12352100
PubChem Substance ID:
24847191
NACRES:
NA.22

Quality Level

200

assay

≥99%

form

solid

mp

250-254 °C (dec.) (lit.)

solubility

H2O: soluble 50 mg/mL

functional group

hydrazine

SMILES string

Cl[H].NNc1ccccc1

InChI

1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H

InChI key

JOVOSQBPPZZESK-UHFFFAOYSA-N

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Application

Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice.

Biochem/physiol Actions

Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals.

Preparation Note

50 gm of Phenylhydrazine hydrochloride dissolves in 1 mL of water to yield a clear, very faint yellow solution.

Related product

Referencia del producto
Descripción
Precios

901183

Propylhydrazine hydrochloride

901209

N-(But-3-yn-1-yl)-4-hydrazineylbenzamide hydrochloride

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCD8581
BCCD8580
BCCC3422
BCCC3421
MKCK8240

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Phenylhydrazine as inhibitor of horseradish peroxidase for use in immunoperoxidase procedures.
W Straus
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 20(11), 949-951 (1972-11-01)
Emanuela Tolosano et al.
Blood, 100(12), 4201-4208 (2002-10-24)
Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and hemopexin are thought to play a crucial role. Haptoglobin and
Y Yamamura et al.
Molecular and cellular biology, 18(3), 1172-1180 (1998-03-06)
Abnormal erythropoietin (EPO)-independent cell growth is induced after infection of erythroid progenitor cells with a polycythemic strain of Friend virus (FVp). Binding of its Env-related glycoprotein (gp55) to the EPO receptor (EPOR) mimics the activation of the EPOR with EPO.
Jason S Nagati et al.
PloS one, 14(11), e0225105-e0225105 (2019-11-15)
The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcription factors include HIF-2, which is activated under conditions of oxygen
Robert Moreau et al.
PloS one, 7(9), e46101-e46101 (2012-10-03)
Sustained erythropoiesis and concurrent bone marrow hyperplasia are proposed to be responsible for low bone mass density (BMD) in chronic hemolytic pathologies. As impaired erythropoiesis is also frequent in these conditions, we hypothesized that free heme may alter marrow and
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