T8931
Thyrotropic hormone from bovine pituitary
Synonym(s):
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
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About This Item
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biological source
bovine pituitary glands
Quality Level
form
powder
packaging
vial of 100 μg
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
Gene Information
cow ... TSHB(281552)
human ... TSHR(7253)
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General description
Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.
Application
Thyrotropic hormone from bovine pituitary has been used:
- to induce cAMP production in orbital fibroblasts.
- as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
- for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
- for studying the thyrotropin involvement in photoperiodic signal transduction in mice.
Biochem/physiol Actions
Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Quality
Contains phosphate buffer salts
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Concentration of thyrotropic hormone in persons occupationally exposed to lead, cadmium and arsenic
Jurdziak M, et al.
Biological trace element research, 182(2), 196-203 (2018)
Disorders of the Hypothalamic-Pituitary-Thyroid Axis
Handbook of Neuroendocrinology, 685-706 (2012)
Endocrine System
Fundamentals of Toxicologic Pathology, 513-551 (2010)
Gen Hiyama et al.
Scientific reports, 8(1), 10012-10012 (2018-07-04)
Biased mating due to female preferences towards certain traits in males is a major mechanism driving sexual selection, and may constitute an important evolutionary force in organisms with sexual reproduction. In birds, although the role of male ornamentation, plumage coloration
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
Lal G, et al.
Cancer, 107(12), 2752-2759 (2006)
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