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SML3488

Sigma-Aldrich

CuATSP

≥98% (HPLC)

Synonym(s):

(SP-4-2)-[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]copper, Cu ATSP, Cu-ATSP

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About This Item

Empirical Formula (Hill Notation):
C18H18CuN6S2
CAS Number:
68341-12-8
Molecular Weight:
446.05
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, Faint brown to dark red

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

CC1=[N]2[Cu]3(SC(NC4=CC=CC=C4)=N2)SC(NC5=CC=CC=C5)=N[N]3=C1C

Biochem/physiol Actions

CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death.
Zilka O, Poon JF, Pratt DA
Journal of the American Chemical Society, 143, 19043-19057 (2021)

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