SML3124

Gemcabene

≥98% (HPLC)

• Synonym(s): 6,6′-Oxybis(2,2-dimethylhexanoic acid), CI-1027, PD72953
• Empirical Formula (Hill Notation): C₁₆H₃₀O₅
• CAS Number: 183293-82-5
• Molecular Weight: 302.41
• MDL number: MFCD00951832
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(O)C(CCCCOCCCCC(C(O)=O)(C)C)(C)C
• InChI: 1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)
• InChI key: SDMBRCRVFFHJKR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Gemcabene is an orally available lipid-regulating compound that induces both a cholesterol and triglyceride reduction by a mechanism of action not linked to agonist or antagonist activity on the PPAR-α receptors. Gemcabene down-regulates apoC-III expression. Gemcabene is primarily metabolized (glucuronidation) by UDP-glucuronosyltransferase2B7 (UGT2B7). Thus, is often used as a UGT2B7 substrate.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable